Harlequins vs Saracens Live Stream,Two of those losses came in the Anglo-Welsh Cup, including a 30-29 home defeat by Quins. Mark McCall’s side then picked up losing bonus points in the 23-17 defeat at Gloucester and the 18-20 home reverse to Premiership champions Exeter.
Renaldo Bothma makes his debut at flanker as Jamie Roberts is back at centre and Elia Elia and George Merrick are named in the pack.
Saracens make seven changes to the XV which lost to Exeter last time out.
England internationals Jamie George, Owen Farrell, Nick Isiekwe, Maro Itoje and Mako Vunipola return to the side.
Richard Wigglesworth forms a new half-back partnership with Farrell as Sean Maitland replaces Nathan Earle on the wing.
Sarries have lost their past four games in all competitions, their worst run of results since 2010.
Harlequins: Brown; Walker, Alofa, Roberts, Visser; Smith, Care; Marler, Elia, Collier, Merrick, Horwill (capt), Bothma, Robshaw, Luamanu.
Replacements: Ward, Boyce, Sinckler, Lamb, White, Kitto, Lang, R. Chisholm.
Saracens: Goode; Maitland, Bosch, Barritt (c), Wyles; Farrell, Wigglesworth; M. Vunipola, George, Koch, Isiekwe, Kruis, Itoje, Clark, Wray.
Replacements: Tolofua, Barrington, Figallo, Skelton, Burger, Spencer, Lozowski, Earle.
Horwill’s men defeated Sarries 17-10 in this fixture last season – and with both teams about to head into the next round of Champions Cup matches, a win over the second-placed side would deliver much-needed momentum.
Sarries’ defeats came while their sizeable international contingent were away and – apart from the injured Wales wing Liam Williams – the north London outfit will arrive in south-west London with all their Test players, including Owen Farrell, Maro Itoje and Mako Vunipola. Williams has a groin injury, while former Springbok hooker Schalk Brits is out until the new year with a muscle problem, yet Sarries are still able to call upon Scotland wing Sean Maitland and Lions hooker Jamie George in those positions.